ll competitive exams Published this article page no 51 application of the technique to human germline until now all therapeutic interventions in humans using genome editing have been performed in somatic cells (i.e. only patient gets affected no chance of inheriting the altered genes by patients offspring). safety concerns have been raised regarding genome editing in human germline where unpredictable changes can be transmitted to following generations ecological impacts a gene drive can propagate a set of genes with negative traits throughout a population which may lead to disappearance of whole targeted population with severe ecological consequences.difficulty in regulation the precise genetic modifications obtained through crispr cas9 technique makes it more difficult to identify a genetically modified organism once outside the lab and also to regulate such organisms in the market. the moral question that arises is whether benefits from the use of such unpredictable technology outweigh potential threats. ethical challenges around gene editing latest general knowledge.
